Abstract
A square wave voltammetry (DPV) method for trans-Pt[Cl2(Dimethylamine)(isopropylamine)] determination is developed. To this end, all the chemical and instrumental variables affecting the determination of trans-Pt[Cl2(Dimethylamine) (isopropylamine)] are optimized. From studies of the mechanisms governing the electrochemical response of trans-Pt[Cl2(Dimethylamine)(isopropylamine)], it was concluded that it was an electrochemically reversible system with an adsorptive oxidation phenomenon. Under optimal conditions, the variation of analytical signal (Ip) with trans-Pt[Cl2(Dimethylamine)(isopropylamine)] concentration was linear in the 0.05 μg·mL-1 to 10 μg·mL-1 range, with a LOD 91 μg·mL-1 of and a LOQ of 303 μg·mL-1, a RSD 1.10% and Er 0.72%. The optimized method was applied to the determination of trans-Pt[Cl2(Dimethylamine)(isopropylamine)] in biological fluids, in human urine and synthetic urine.
Highlights
In the 40 years since the discovery of cisplatin, hundreds of new platinum (II)- and platinum (IV)-based complexes have been synthesised and tested as anticancer drugs [1]
The optimized method was applied to the determination of trans-Pt[Cl2(Dimethylamine)(isopropylamine)] in biological fluids, in human urine and synthetic urine
The electrochemical study of the Pt(II) complex trans-[PtCl2(dimethylamine)] was performed by differential pulse voltammetry (DPV) and square wave voltammetry in order to determinate the best conditions for its determination
Summary
In the 40 years since the discovery of cisplatin, hundreds of new platinum (II)- and platinum (IV)-based complexes have been synthesised and tested as anticancer drugs [1]. Whilst cucurbit [6] uril (CB [6])was first discovered in 1905 by Behrend et al [14], its macrocyclic structure was not determined until 1981 [15] and until 2000, CB [6] was the only cucurbit [n] uril to receive any attention as a molecules useful in host-guest chemistry This changed upon the discovery of different sized cucurbit [n] urils: CB [5], CB [7], CB [8] and the isolation of free CB [10] ((compound 3, 5, 6, Figure 1) [16,17]. The analysis of biological fluids presents a special relevance because small changes in the concentration of its components are through to be correlated with several neurological or metabolic disorders
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