Use of Corifollitropin Alfa in a Hispanic Cohort After Previously Failed Traditional Ovarian Stimulation Cycle [32A

Abstract

INTRODUCTION: The aim was to assess reproductive outcomes of corifollitropin alfa (CA) in the same cohort of patients who had before an Intracytoplasmic sperm injection cycle with a traditional controlled ovarian stimulation (COS) protocol using daily (rFSH/uhMG). METHODS: Retrospective cohort; forty couples included. Traditional COS received rFSH plus uHMG. Second cycle received 100 or 150 µg of CA, in both cycles patients had antagonist protocol and fresh embryo transfer. RESULTS: Mean age 34 ± 4.9 years. Compared traditional COS using (rFSH/uhMG) vs CA, there was a difference in peak of estradiol (mean±SD) (1984.9±1292 vs 1099±812 pg/mL, P<.05). No significant differences founded on: progesterone level (1.3±2 vs 1±2.4), endometrial thickness (9.3±1.8 vs 9.4±1.4), mean number of oocytes retrieved (7.1 ± 4.4 and 6.6 ± 5.4), metaphase II oocytes (MII) retrieved (49.8% vs 55.8%), fertilization rate (62.6% vs 67.4%) and number of embryos transferred (1.69 vs 1.61), for (rFSH/uhMG) and CA respectively. The number of blastomeres on day 3 of embryo culture was significantly different in favor of the CA cycle (6.4 ± 1.3 vs 5.5 ± 1.2, P<.05). Positive hCG per transfer was higher on the corifollitropin cycle (6.8% vs 41.38%, P<.05). CONCLUSION: This study allowed us to assess the effects of CA on the same cohort of patients; results suggest that the reproductive outcomes of patients treated with CA are similar, with the advantage of having a convenient one application and lower level of estradiol. More studies are needed to determine whether CA has an impact on embryo development in certain groups of patients.