Use of controlled pore glass in solid phase oligosaccharide synthesis. Application to the semiautomated synthesis of a glyconucleotide conjugate

Abstract

Abstract Three polymeric supports (polystyrene, Tentagel and controlled pore glass) have been tested for solid phase synthesis of oligosaccharides based on the trichloroacetimidate methodology. Controlled pore glass has been found to yield satisfactory results with TMSOTf as the glycosylation promoter. An application to the on-line preparation of a glyconucleotide is also reported.