Abstract
Centrifugal partition chromatography (PC) was examined as a technique for measuring the partition coefficient of organic solutes. Two solvent systems of convenient viscosity were used, namely n-hexanol—water and cyclohexane—water. The partition coefficients thus determined (expressed as log P CPC/ol and log P CPC/ane, respectively) were shown to be well correlated with literature partition coefficients obtained by the shake-flask (SF) method in the n-ocatnol—water and n-hexane—water systems, respectively. Hydrogen-bonding parameters, I H , were calculated as (log P CPC/ol − log P CPC/ane) and (log P oct − log P hex); the good correlation between the I H values derived from the CPC and SF methods indicates that the same partitioning mechanism is operative in both methods.
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
