Abstract
Laboratory animals are fundamental to study immunological aspects and the efficacy of new drugs to treat leishmaniasis. However, we do not have practical and good animal models to study leishmaniasis caused by Leishmania (Viannia) braziliensis - L(V)b. In this study, thirty-two experimental animals (Cavia porcellus) were injected in the hind foot with 3x105 promastigote forms of L(V)b. The animals were followed for eight weeks. None of the experimental animals developed lesions or presented the parasite in any of the tests performed (histopathological exam, smears, culture, inoculation in hamsters, and polymerase chain reaction).
Highlights
American tegumentary leishmaniasis (ATL) is in frank expansion in Brazil and all over the world [8]
We do not have practical and good animal models to study leishmaniasis caused by Leishmania (Viannia) braziliensis - L(V)b
New drugs have been discovered to act against leishmaniasis, and laboratory animals are fundamental to study the efficacy of these drugs
Summary
American tegumentary leishmaniasis (ATL) is in frank expansion in Brazil and all over the world [8]. The vectors and the reservoirs are difficult to control, since they are generally wild and some may not be known yet. Leishmania (Viannia) braziliensis - L(V)b - is an important etiologic agent in Brazil due to its high morbidity, principally by the compromising of mucous membranes, which, in some cases, leads to deformations of the facial region and death [10, 13]. The usual control measure for ATL is treatment of the infected individual. Previous studies on the inoculation of Leishmania (Viannia) braziliensis and Leishmania (Leishmania) guyanensis in Cavia porcellus showed promising results [11, 15]. Our objective was to verify the susceptibility of Cavia porcellus to infection by L(V)b
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