Use of Cationized Ferritin Nanoparticles to Measure Renal Glomerular Microstructure with MRI

Kevin M Bennett,John F Bertram,Teresa Wu,Jennifer R Charlton,Scott C Beeman,Min Zhang,Bradley D Hann,Edwin J Baldelomar

doi:10.1007/978-1-4939-3353-2_7

Use of Cationized Ferritin Nanoparticles to Measure Renal Glomerular Microstructure with MRI

Kevin M Bennett, John F Bertram + Show 6 more

https://doi.org/10.1007/978-1-4939-3353-2_7

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Publication Date: Dec 17, 2015

Citations: 9

Affiliation: University of Hawaiʻi at Mānoa, Monash University, Decision Systems (United States), Arizona State University, University of Virginia Medical Center, Washington University in St. Louis

#Cationic Ferritin #Magnetic Resonance Imaging + Show 8 more

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Abstract

Magnetic resonance imaging (MRI) is becoming important for whole-kidney assessment of glomerular morphology, both in vivo and ex vivo. MRI-based renal morphological measurements can be made in intact organs and allow direct measurements of every perfused glomerulus. Cationic ferritin (CF) is used as a superparamagnetic contrast agent for MRI. CF binds to the glomerular basement membrane after intravenous injection, allowing direct, whole-kidney measurements of glomerular number, volume, and volume distribution. Here we describe the production, testing, and use of CF as an MRI contrast agent for quantitative glomerular morphology in intact mouse, rat, and human kidneys.

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