Abstract
The time course and defining factors involved in the formation of neurofibrillarytangles (NFT) and senile plaques (SP) in Alzheimer's disease (AD) brainare unknown. Above ground nuclear weapons tests led to significantly increasedlevels of 14C in the carbon cycle. Because SP and NFT are relativelyresistant to degradation, the 14C levels in SP and NFT should reflecttheir year of formation. Through the use of accelerator mass spectrometry(AMS) and the measurement of 14C levels, we have determined theaverage age of formation of isolated SP and NFT fractions of 6 AD subjects.While a heterogeneous process of formation is indicated, NFT pre-date SP inthe majority of cases. In addition, it is clear that NFT and SP have a muchslower carbon turnover rate than normal brain tissue.
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