USE OF BODY COMPOSITION STUDIES FOR THE EVALUATION OF CHANGES IN NUTRITIONAL STATUS IN CYSTIC FIBROSIS (CF) CHILDREN. 750

Abstract

We evaluated the changes of different body compartments in 15 CF children while on lansoprazole (a proton pump inhibitor, which together with pancreatic enzymes can improve steatorrhea and nutrition in CF) for a 3 months period using anthropometric, TBW (Deuterium water) and DXA (dual energy X-ray absorptiometry) methods. There were 10 boys and 5 girls with a mean age and body mass index (BMI) of 9,5 years and 15,6 resp. Weight, height, skinfolds(biceps, triceps, subscapular, suprailiac), DXA and TBW body composition were measured before and 3 months after lansoprazole when the nutritional condition, assessed by anthropometric method, improved significantly (data not shown).The intermethod correlation coefficients before and after lansoprazole for fat free mass (FFM) were 0,99 (p = 0,001) for all comparisons. Fatmass(FM) correlation coefficients were 0,98; 0,97; and 0,96 (p = 0,001) for DXA-skinfolds, DXA-TBW and Skinfold-TBW resp. The changes in FM, FFM, bodyweight (BW) and DXA calculated weight (TM) were as below. Both, skinfold and DXA body composition methods mainly attributed weight changes to changes in FM, while TBW method results attributed it to changes in FFM. No correlation was found between weight changes and either FM or FFM changes by any method. Conclusion, although body composition methods can detect small changes in bodyweight,they are not accurate enough for detecting the small changes in FM and FFM. Table