Abstract
Objectives: Treatment of osteoarthritis (OA) using autologous conditioned serum (ACS) has become in recent years an alternative to consider in the approach of the degenerative joint disease of the knee. There is no support in the literature for the use of ACS for the treatment of OA of the temporomandibular joint (TMJ), although the promising results obtained in human patients with knee joint disease as well as in animal studies are opening the way for its use at the TMJ. The aim of this paper is to conduct a review of the published literature regarding the use of the ACS for the treatment of OA in humans, considering the level of scientific evidence, and following the principles of the evidence-based medicine and dentistry. Material and Methods: A PubMed-MEDLINE search was carried out of articles published between 1980 and 2011. After an initial search, a total of 102 articles were obtained, followed by a selection of the most relevant articles according to the topic; a total of 8 articles were selected, which were stratified according to their level of scientific evidence using SORT criteria (Strength of Recommendation Taxonomy). Results: At the time of this review, there is no available literature referring the use of ACS at the TMJ. However, the use of the ACS in other joints is well documented, both experimentally and clinically, in humans and animals. The reviewed articles, with a level of evidence 1 and 2 according to the SORT criteria, have generally promising results. Discussion and Conclusions: The use of ACS in the treatment of OA in joints other than the TMJ, is endorsed by the level of evidence found in the literature, which opens the door to future studies to determine the feasibility of the use of the ACS in the treatment of degenerative OA that affects TMJ. Key words:Osteoarthritis, temporomandibular joint, autologous conditioned serum.
Highlights
Osteoarthritis (OA) of the temporomandibular joint (TMJ) is a common pathology
The use of Autologous conditioned serum (ACS) in the treatment of OA in joints other than the TMJ, is endorsed by the level of evidence found in the literature, which opens the door to future studies to determine the feasibility of the use of the ACS in the treatment of degenerative OA that affects TMJ
The initial PubMed-MEDLINE search provided a total of 43891 articles for the term “Osteoarthritis”, 20440 articles on “TMJ”, 102 for the term “Autologous Conditioned Serum” and 6 items on “Orthokine”
Summary
Osteoarthritis (OA) of the temporomandibular joint (TMJ) is a common pathology. It appears as a degenerative, progressive, slow evolution pathology, which affects TMJ, both hard and soft tissues. Radiographic changes of the TMJ associated with OA are present in 17% of patients over 65 years; 50% of those have a mild to moderate degree (or worse) level of pain and dysfunction in their jaw, which would reduce the 17% figure in individuals over 65 years of age to 8.5% with substantial clinical symptoms (1). It is no clear what the prevalence of TMJ OA is in younger population. Surgery should be considered as a treatment option for severe, restrictive OA
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
