Abstract
The third-generation aromatase inhibitor group includes letrozole, and anastrozole and exemestane have both been approved for suppression of estrogen in postmenopausal women with breast cancer. It seems scientifically plausible that various gynecological disorders that are estrogen dependent would benefit from estrogen suppression by aromatase inhibitors. When an aromatase inhibitor is used in premenopausal women, blocking an endogenous rise of gonadotropins by gonadotropin-releasing hormone analogs or sex steroids is mandatory to achieve adequate estrogen suppression. The two most frequently investigated gynecological conditions for the use of aromatase inhibitors include infertility and endometriosis. Available evidence strongly supports the success of aromatase inhibitors for the induction of ovulation, and reducing the pain associated with endometriosis. Preliminary evidence of success in managing other gynecological disorders, such as uterine leiomyomas, exists. Bone loss and dyslipidemia are potenti...
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
