Use of Antibacterial Envelopes for Prevention of Infection in Intrathecal Pump Implantation

Abstract

Intrathecal pumps for targeted delivery of baclofen for spasticity or morphine/hydromorphone for chronic pain are attractive treatment options for a variety of conditions, with increasing utilization. Placement of these devices carries a historic infection rate as high as 12%. Treatment of pump-related infection includes removal of the system, potentially leading to dangerous medication withdrawal. TYRX antibacterial envelopes (Medtronic Inc., Minneapolis, MN), which are absorbable mesh envelopes that elute minocycline and rifampin, have been used in implantable cardiac devices with substantial risk reduction for infection.