Abstract
Background: There is a large amount of evidence that anti-angiogenic drugs are effective safe. However, few studies have evaluated the specific effects of anti-angiogenic drugs on myocardial enzyme injury biomarkers: aspartate aminotransferase (AST), lactic dehydrogenase (LDH), creatine kinase (CK) and creatine kinase isoenzyme (CK-MB). The purpose of our study was to determine whether anti-angiogenic drugs serum AST, LDH, CK, and CK-MB activities of cancer patients treated with anti-angiogenic drugs.Methods: This study retrospectively analyzed 81 cancer patients. Patients who had used anti-angiogenic drugs were selected. Serum AST, LDH, CK, and CK-MB activities were measured before and after treatment with anti-angiogenic drugs for 3 weeks.Results: A total of 16 cancer types were analyzed. The distribution of the cancer types in the patients was mainly concentrated in lung, gastric, and colorectal cancers. The anti-angiogenic treatment markedly increased AST, LDH, CK, and CK-MB activities by 32.51, 7.29, 31.25, and 55.56%, respectively in serum.Conclusions: Our findings suggest that patients, who had used anti-angiogenic drugs were likely to have elevated AST, LDH, and CK, indicators of myocardial muscle injury. Use of anti-angiogenic drugs should not be assumed to be completely safe and without any cardiovascular risks.
Highlights
Anti-angiogenic treatment is an effective and targeted therapy strategy that can be used to control and kill tumors [1]
From Jan 2014 to Dec 2020, cancer 81 patients treated with apatinib, anlotinib, regorafenib, bevacizumab, sorafenib, or sunitinib at the oncology department, Guang’anmen hospital, China Academy of Chinese Medical Sciences were retrospectively recruited for this study
A total of 81 patients were treated by anti-angiogenic drugs during the study period
Summary
Anti-angiogenic treatment is an effective and targeted therapy strategy that can be used to control and kill tumors [1]. Chemotherapeutics can kill tumor cells, the remaining tumor cells can still survive and continue to grow due to the support of peripheral blood vessels. Abnormal tumor blood vessels reduce the delivery of drugs into tumor tissues, which leads to limited efficacy of anti-cell proliferation therapy. Anti-angiogenic drugs can be used to bind to VEGF to prevent it from. There is a large amount of evidence that anti-angiogenic drugs are effective safe. Few studies have evaluated the specific effects of anti-angiogenic drugs on myocardial enzyme injury biomarkers: aspartate aminotransferase (AST), lactic dehydrogenase (LDH), creatine kinase (CK) and creatine kinase isoenzyme (CK-MB). The purpose of our study was to determine whether anti-angiogenic drugs serum AST, LDH, CK, and CK-MB activities of cancer patients treated with anti-angiogenic drugs
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