Abstract
We read the article by Pang et al<sup>1</sup>concerning the use of frog skin for the differentiation of bullous pemphigoid (BP) from epidermolysis bullosa acquisita (EBA). Based on sporadic observations of a floor-pattern indirect immunofluorescence on 1 mol/L of sodium chloride—split skin (SSS) obtained from BP sera, these authors used skin from a toad to establish a differential diagnosis between BP and EBA. Their rationale was the fact that, as suggested by earlier studies, the BP antigen is present in the skin of some animals,<sup>2</sup>from which the EBA antigen—being phylogenetically more restricted—is absent.<sup>3</sup>Since this procedure seems attractive, we undertook a retrospective comparative study to better delineate the usefulness of animal skin substrates for the diagnosis, using indirect immunofluorescence, of subepidermal autoimmune bullous diseases. During the last 3 years, we screened over 1500 human serum samples sent to us under the suspicion of a subepidermal autoimmune
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
