Abstract
AbstractAffinity-purified rabbit antibody to human lambda and kappa chains (RαHλκ) was conjugated to the A-chain of the plant toxin, ricin. The resulting immunotoxin (RαHλκ) killed cells from the tumor cell line Daudi, which bears surface immunoglobulin, but was nontoxic to the CFU-E, BFU-E, and CFU-GM of human bone marrow. RαHλκ eliminated 99% of clonogenic Daudi cells that had been mixed with marrow cells in vitro, without demonstrable toxicity to hematopoietic cells. Thus, in vitro treatment of marrow with RaHXx-A may increase the incidence of cure following autologous bone marrow transplantation for the treatment of human B-cell malignancies.
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