Abstract

Abstract AMPHOTERICIN, an antifungal antibiotic, has been used successfully in the treatment of mycotic diseases of humans. Amphotericin is related chemically to nystatin (Mycostatin®) * (Vandeputte et al., 1955). It was of interest to compare this new antifungal agent with nystatin with respect to its ability to prevent moniliasis as measured by incidence of crop mycosis in chicks and turkeys. Previous work by Yacowitz et al. (1958, 1959a, b) and Wind and Yacowitz (1960) has shown that nystatin was effective in preventing moniliasis in experimentally infected birds. Gentry et al. (1960) reported effective treatment of Candida albicans crop infection in a turkey flock with nystatin. Yacowitz et al. (1959b) had previously shown that amphotericin A and B were not toxic to chicks. In the present paper data are presented demonstrating the anti-fungal activity of amphotericin and comparing the activity of this antifungal agent with that of nystatin. MATERIAL AND METHODS Day old…

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