Abstract
The high prevalence of sepsis in intensive care units and emergency rooms, along with the high lethality of the sepsis cases makes the study of pathophysiology of sepsis critically important. As a preclinical model, endotoxemia is an important tool to study the pathophysiology of sepsis and septic shock. In this review, we discussed aspects of endotoxemia as an experimental model in sepsis research, including different techniques associated with the purification of the endotoxin of Escherichia coli, serotype dependency and dosage dependency of the experimental results.
Highlights
Despite advances in critical care medicine, development of new therapeutic approaches including new supportive care programs, establishment of new health care protocols and policies, severe sepsis and septic shock continue to be prevalent in intensive care units and emergency rooms
The high prevalence of sepsis in intensive care units and emergency rooms, along with the high lethality of the sepsis cases makes the study of pathophysiology of sepsis critically important
Endotoxemia is an important tool to study the pathophysiology of sepsis and septic shock
Summary
Despite advances in critical care medicine, development of new therapeutic approaches including new supportive care programs, establishment of new health care protocols and policies, severe sepsis and septic shock continue to be prevalent in intensive care units and emergency rooms. The incidence of sepsis and attempted to project the mortality rates of sepsis One of such studies [8] examined discharge data on approximately 750 million hospitalizations in the United States over a period between 1979 and 2000 and identified more than 10 million cases of sepsis, with the results of the study showing an annualized increase in the incidence of sepsis of 8.7 percent, from approximately 164,000 cases (82.7 per 100,000 population) to nearly 660,000 cases (240.4 per 100,000 population) [8]. Letarte et al [3] conducted a study investigated the costs of severe sepsis and septic shock in Quebec, Canada. We will attempt to discuss the serotype dependency of the experimental results and present experimental data. We will discuss the dosage dependency of the experimental results with regard to clinical effects to be observed
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
