Abstract
The effectiveness of tris (hydroxymethyl) aminomethane (THAM) in increasing salicyluria after intravenous injection of sodium salicylate was tested in experiments on 4 dogs. A marked drop of salicylate in plasma and increase in its excretion in urine was demonstrated. These experiments also indicate that maximum excretion of salicylate by the kidney will occur when an elevation of body fluid pH and urine pH are accompanied by a marked diuresis. THAM, which promotes these changes, may be useful in treatment of salicylate poisoning in man.
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