Abstract
BackgroundThe use of alloplastic meshes has been historically contra-indicated in patients with infection.AimTo evaluate the use of polypropylene meshes in the treatment of abdominal wall defects in rats with peritonitis.MethodsTwenty Wistar female rats were divided into two groups: induction of peritonitis (test group) and without peritonitis (control group). An abdominal wall defect was created in all animals, and polypropylene mesh was applied. The evaluation of the tensile strength of the mesh was carried out using tensiometer and microscopic analysis of the healing area was done.ResultsMore adhesion of the mesh to the rat abdominal wall was observed in test group. The histopathological analyses showed prevalence of moderate to accentuated granulation tissue in both groups, without significant differences.ConclusionThe use of the mesh coverage on abdominal wall defects of rats with induced peritonitis did not show worse results than its use in healthy animals, nor was its integration to the resident tissue any worse.
Highlights
The treatment of abdominal wall hernias with synthetic meshes was first described by Usher in the 1950s and heralded a new era of surgical history[18]
Twenty Wistar female rats with weight ranged from 250 to 310 g were distributed into two experimental group: 1) test group: induction of peritonitis, creation of abdominal wall defect, mesh repair and evaluation of tensile strength after seven days; 2) control group: absence of peritonitis, creation of abdominal wall defect, mesh repair and evaluation of tensile strength after seven days
Suture dehiscence was observed in 11 animals, five in rats with peritonitis and six in control group
Summary
The treatment of abdominal wall hernias with synthetic meshes was first described by Usher in the 1950s and heralded a new era of surgical history[18]. The characteristics of these meshes present the advantages observed in biomaterials, such as inertia in the presence of infection and the ability to maintain tensile strength. In many abdominal procedures, contaminated ones and even infected ones, the means to perform an effective laparorraphy are required Some clinical situations, such as patients with perforated digestive tract tumors and peritonitis, the elderly, critically ill and severely injured patients that require to be operated on the abdomen, would benefit from primary repair rather than being submitted to another operation
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