Abstract
Approaches to treating cognitive-amnestic disorders of various origins, including Korsakoff's syndrome (KS), are currently being actively elaborated. KS is manifested by severe memory impairment, leading to disability. It is quite common in alcohol abusers. There is still no proven effective treatment for KS. In view of the fact that studies on the treatment of KS have been very few, there are no clear recommendations for its most effective treatment. There has been evidence that in addition to thiamine deficiency, the toxic effect of glutamate that is actively released through binding to NMDA receptors during the ethanol withdrawal period is the basis for KS development. Memantine, a noncompetitive NMDA receptor antagonist, has recently been used successfully to treat KS. The paper describes a clinical case of a 55-year-old patient with KS treated with akatinol memantine, in which the latter has demonstrated its high efficacy and good tolerance. Analysis of the data available in the literature and the presented clinical case suggest that it is advisable to prescribe memantine for patients with alcohol-related memory impairment.
Highlights
В настоящее время активно разрабатываются подходы к лечению когнитивно-мнестических расстройств различного генеза, в том числе корсаковского синдрома (КС)
Korsakoff's syndrome (KS) is manifested by severe memory impairment, leading to disability
There has been evidence that in addition to thiamine deficiency, the toxic effect of glutamate that is actively released through binding to NMDA receptors during the ethanol withdrawal period is the basis for KS development
Summary
В настоящее время активно разрабатываются подходы к лечению когнитивно-мнестических расстройств различного генеза, в том числе корсаковского синдрома (КС). На фоне проводимого лечения состояние несколько улучшилось: понимал, что находится в больнице, но попрежнему путался в датах и именах, уменьшилась тревога, улучшился сон, стабилизировалось настроение. Значительно ухудшилась память на текущие события: не мог вспомнить, где находится магазин, забывал имена близких, не мог сказать, что делал накануне, путался при выполнении повседневных дел.
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
