Abstract
A Revista Brasileira de Cirurgia Plástica é o órgão oficial de divulgação da Sociedade Brasileira de Cirurgia Plástica (SBCP), tem como objetivo registrar a produção científica em Cirurgia Plástica, fomentar o estudo, aperfeiçoamento e atualização dos profissionais da especialidade.
Highlights
Complex wounds pose a challenge to the plastic surgeon
Skin healing is a dynamic process and involves cellular interaction, the extracellular matrix (ECM), and growth factors that are responsible for the tissue reconstruction or healing that follows the injury process[1,2,3]
Inflammatory substances increase the levels of proteases, which degrade components of the ECM, stimulating the release of growth factors, proteins, and receptors that are essential for wound healing[2,3,5]
Summary
Complex wounds pose a challenge to the plastic surgeon In these cases, the most common solution is skin grafting or the use of flaps; depending on the affected structure, the results may not be satisfactory. The ECM plays an important role in tissue regeneration and is the largest component of the dermis It is composed of proteoglycans, hyaluronic acid, collagen, fibronectin, and elastin[4]. The recognition of the importance of the ECM in the healing process and tissue repair has led the pharmaceutical industry to develop biomaterials that could stimulate or replace the ECM. These biomaterials, resulting from tissue engineering, mimic the structural and the functional characteristics of the natural ECM6
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