Use of a Suspoemulsion to Improve Bioavailability of a DCS Class IV Compound

Abstract

Enabling formulations are used by the pharmaceutical industry to help improve bioavailability of compounds with low solubility and permeability properties.  Suspoemulsions are a combination strategy of using permeation enhancers in a lipid phase, with drug molecules incorporated as a solid nanosuspension in the aqueous phase to maximise oral exposure.  Here, a suspoemulsion is created by bead milling a classical drug suspension to reach nano size range and combining with a lipid blend of Labrasol ALF and Capmul MCM.  This formulation increased oral bioavailability from 5% to 24%.  The exact mechanism of this improvement is hypothesised but would need further work to establish.