Abstract
Dietary conjugated linoleic acid (CLA) has been reported to decrease backfat and increase marbling in pigs. The objective of this study was to determine the effect of CLA on lipid accumulation in mouse muscle. Male mice (n=80) were fed 7% soy oil (SO) or coconut oil (CO) diets for 6 wk, then 0 or 0.5% CLA was added for 12 d. A body fat index was calculated and muscle lipid content was determined by ether extraction. Fatty acid β ‐oxidation was indicated by determining the enzyme activity of carnitine palmitoyl‐transferase (CPT)‐1. Body fat was reduced by CLA (P < 0.05). CLA caused a 28% decrease (P < 0.01) in thigh muscle lipid and a non‐significant (P = 0.22) 24% decrease in back muscle lipid. CPT‐1 activity in thigh muscle was decreased by CLA (P < 0.01) in SO‐fed mice (80.94 vs. 14.27 EU/mg protein) but not in CO‐fed mice (38.86 vs. 12.49 EU/mg protein). These results appear to indicate that mice do not accumulate muscle lipid in response to dietary CLA as do pigs. Also the reduction in muscle CPT‐1 activity caused by CLA might be associated with the reduction of fatty acids available for β‐oxidation, so the effect of CLA may be time‐dependent.Grant Funding Source: West Virginia University
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