Abstract
An optical nondestructuve microprobe technique is proposed to examine cell surfaces in vitro. Use is made of the phenomenon of total internal reflection to achieve spatially restricted interaction between a light beam and the peripheral zone of a substrate-adherent population of cells. With the help of a suitable optical model, the technique can provide fundamental information on the molecular organization of the cell membrane from measurements made on living cells. Variations of both the intensity and polarization ellipse of the reflected beam carry information about changes in the cell surface that can be induced by any stimulus to which the cells are subjected. This promises to have important applications such as the detection of normal-to-malignant cell transformations.
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