Abstract
A newly-synthesised dimethylated chlorocyclodiene epoxide is metabolised by NADPH-supplemented rat liver microsomes to produee either one or both of two major metabolites. M1 and M2. Microsomes from adult male rat liver produce both metabolites. By contrast, microsomes made from the livers of mature or immature female rats make only metabolite M1, as do hepatic microsomes from pre-pubertal male rats. Male rats castrated when 7 days old provide liver microsomes that make little of metabolite M2 upon killing at 3–5 months post partum. After induction with phenobarbital, microsomes from adult male and female rat liver make metabolites M1 and M2. together with a further unidentified metabolite. After induction with 3-methylcholanthrene, hepatic microsomes from mature female rats continue to make only metabolite M1 but to make it in larger quantities. These differences, which appear to result from the activity of three or more mono-oxygcnases. could possibly he exploited to monitor the mono-oxygenase status of rat liver microsomes.
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