Abstract
The cardiovascular effects of glucagon were determined in anaesthetized dogs. Glucagon increased heart rate and myocardial contractility. Aortic, renal, and mesenteric flow increased. Neither the cardiac nor vascular dilating actions of glucagon were prevented by β-adrenergic blockade. Glucagon had a biphasic effect on carotid artery flow; an initial increase followed by a decrease. With femoral flow the initial response was variable, but the late response was usually a decrease in flow. These results were seen with intravenous injection. Intra-arterial injection of glucagon produced an increase in mesenteric, renal, carotid, and femoral flow. Results obtained with the intravascular catheter tip electromagnetic velocity probe were similar to those obtained with the external electromagnetic cuff flowmeter. An important advantage of the catheter tip probe over the cuff probe was that the former could be manipulated into various arteries via a small incision in a peripheral artery, thus avoiding extensive surgical dissection.
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