Abstract
A model study has demonstrated that phosphorylation of a highly hindered hydroxyl group can be achieved via sequential treatment with (1) 2-trimethylsilylethyl dichlorophosphite, (2) 2-trimethylsilylethyl alcohol, and (3) hydrogen peroxide. The resulting triester survives a variety of reaction conditions but may be cleaved with fluoride ion to afford the phosphate monoester.
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