Use of 2-alkoxy-1-alkoxycarbonyl-1,2-dihydroquinolines as condensing agents in the synthesis of intermediate fragments of the 1?4 sequence of ACTH

Abstract

The use of 2-alkoxy-l-alkoxycarbonyl-1,2-dihydroquinolines as a condensing agent in a number of stages in the synthesis of fragments of the 1–4 sequence of ACTH is considered. In a number of cases, these compounds have successfully replaced dicyclohexylcarbodiimide, which is a strong allergen. All the compounds described were obtained in satisfactory yields and had fairly high purities. They were characterized from their angles of optical rotation, chromatographic mobilities, and melting points. The conditions for performing the reaction and some physicochemical characteristics of the compounds synthesized are presented.