Use and experience with six-monthly paliperidone in the Campo de Gibraltar area. Descriptive study.

Abstract

IntroductionLong-acting injectable antipsychotics have demonstrated advantages over therapeutic adherence and can reduce the rates of relapses and due to treatment discontinuation. The novel presentation of paliperidone palmitate six-month (PP6M) can simplify the treatment to two injections per year.ObjectivesThe purpose of the present research is to describe the profile of patients receiving this novel treatment in our area. For this, a descriptive study has been carried out.MethodsWe have collected and analyzed data from a total of 8 patients from the global long-acting injectable nursing registry in our area. The data collection was from May 2022 to October 2022.ResultsID PatientAge GenderMedical comorbidities Social supportAdherence to previous LAIEP001AGC52MNo-YesEP002EGA53MNoLowNoEP003ESL45FYesHIV, HCV, dyslipidemia,EnoughYesEP004ACG60MYesHypertension, dyslipidemiaGoodYesEP005DCP52MYesCOPDEnoughYesEP006ATT47MNoEnough / LowYesEP007AH40FYesTension headacheEnoughYesEP008IAR66FYesType 2 diabetes mellitus, hypertension, hyperuricemiaEnoughYes ID Patient Diagnosis Refractory positive symptoms Last H. Polypharmacy Previous injection Injection date / DoseH. / Side EffectsEP001AGCParanoid schizophrenia-08/03/2014NoPP3M525mg17/05/221.000 mgNoEP002EGASchizoaffective disorderYes19/08/2022YesValproic acid 1.000mgPP1M150mg(once)13/09/221.000mgNoEP003ESLParanoid schizophreniaNo17/04/2019YesOlanzapine 10mgBZDPP3M525mg10/08/221.000mgSedation (low)EP004ACGParanoid schizophreniaNo-YesQuetiapine 50mgPP3M525mg16/09/221.000mgNoEP005DCPParanoid schizophreniaNo16/01/2004YesOlanzapine 20mgBZDPP3M525mg11/10/221.000mgNoEP006ATTPersistent delusional disorderYes-NoPP3M525mg19/09/221.000mgNoEP007AHParanoid schizophreniaNo2017NoPP3M525mg03/08/221.000mgNoEP008IARPersistent delusional disorderYes-YesBZDPaliperidone oral 9mg and laterPP3M350mg(twice)18/10/221.000mgNoFig. 1: Sociodemographic characteristics and Fig. 2: Clinical characteristics.ConclusionsNone of the patients required hospitalization at the time of the study, although this work team considers that it is early to make conclusions in this regard. No serious or minor adverse effects were reported in any of the cases during the time of the investigation, apart from one case of mild sedation.The clinical characteristics of most patients were psychopathological stability and good adherence to previous treatment. Although this study shows that the drug was also used in patients who did not meet these characteristics, specially one case of poor social support. The data collected show that the profile of the patient in whom the drug has been prescribed can be varied and broad.Disclosure of InterestNone Declared