Usage of nanocrystalline cellulose phosphate as novel sustained release system for anti-inflammatory drugs

Abstract

Nanocrystalline cellulose has become significantly important support for the development of drug delivery systems. Generally prepared by sulphuric acid, under hot conditions, results in very low yields. The resulting nanocrystalline cellulose sulphate can exert inflammatory disorder as reported in literature. Therefore, in the present work, we report phosphorylated form of nanocrystalline cellulose as an alternate to sulphate form for sustained release of nonsteroidal antiinflammatory drugs after modification with Cetyl trimethylammonium cation. Binding was directly affected by log P value of drugs. Diclofenac Sodium was found to bind maximally followed by ibuprofen, etodolac and paracetamol in that order. Time dependent serum protein protecting and anti-cathepsin activities suggested that modified nanocrystalline cellulose phosphate served as a sustained release system over a period of 3h. The results for phosphate had an edge over previously reported sulphate. Experimental design has been explained using Molecular modeling studies.