Urotensin 2 and Oxidative Stress Levels in Maternal Serum in Pregnancies Complicated by Intrauterine Growth Restriction.

Esra Celik,Seyithan Taysi,Ahmet Celik,Hasan Ulusal,Emin Sevincler,Seyhun Sucu

doi:10.3390/medicina55070328

Esra Celik, Seyithan Taysi + Show 4 more

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https://doi.org/10.3390/medicina55070328

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Abstract

Background and objectives: In this study, the aim was to investigate Urotensin 2 (U-II) levels and oxidant/antioxidant system parameters in pregnancies with intrauterine growth restriction (IUGR). Materials and Methods: A total of 36 healthy, pregnant women who had not been diagnosed with IUGR and 36 pregnant women who had been diagnosed with IUGR at the Obstetrics and Gynecology Outpatient Clinic at Gaziantep University Hospital were enrolled in this study. The serum total antioxidant status (TAS), total oxidant status (TOS), thiol-disulfide levels, U-II measurements, and oxidative stress index (OSI) calculations were carried out at the biochemistry laboratory at Gaziantep University. Results: According to this study, there was no statistically significant difference between the group with IUGR and the control group of healthy, pregnant women in terms of total antioxidant status (TAS), total oxidant status (TOS), oxidative stress index (OSI), native thiol, total thiol, disulfide, disulfide/native thiol, disulfide/total thiol, native thiol/total thiol, and U-II values. There was, however, a positive linear correlation between TOS and total thiol levels in the group with IUGR (p = 0.021, r = 0.384), and a positive linear correlation between OSI and total thiol values in the control group (p = 0.049, r = 0.330). In addition, there was a negative correlation between disulfide levels and gestational weeks at birth in the group with IUGR (p = 0.027, r = 0.369). Conclusions: Consequently, there was no significant difference between the control group and the group with pregnancies complicated by idiopathic IUGR in terms of serum oxidant/antioxidant system parameters and U-II levels. It is necessary to conduct more extensive studies evaluating placental, maternal, and fetal oxidative stress in conjunction in order to investigate the role of oxidative stress in IUGR.

Highlights

Intrauterine growth restriction (IUGR) is a serious complication of pregnancy and causes significant neonatal mortality and morbidity [1]
Conclusions: there was no significant difference between the control group and the group with pregnancies complicated by idiopathic intrauterine growth restriction (IUGR) in terms of serum oxidant/antioxidant system parameters and U-II levels
It was investigated as to whether different clinical signs observed in these two conditions stemmed from different underlying placental pathologies, or different maternal responses to the same placental pathology, and reported that inhibition of protein synthesis secondary to endoplasmic reticulum stress provided an explanation for the small placental phenotypes observed in both conditions; other pathways that are activated by more severe endoplasmic reticulum stress were only observed in the placentas of pregnancies associated with early-onset preeclampsia

Summary

Introduction

Intrauterine growth restriction (IUGR) is a serious complication of pregnancy and causes significant neonatal mortality and morbidity [1]. Studies have shown that poor fetomaternal circulation, genetic disorders, pregnancy-related hypertensive disorders, diabetes, perinatal infections, maternal malnutrition, exposure to toxins, and drug use are the factors that contribute to IUGR [2] Even so, these factors account for some IUGR cases, whereas others are referred to as “idiopathic”, in which case, placental insufficiency is the most common cause of IUGR [3]. Results: According to this study, there was no statistically significant difference between the group with IUGR and the control group of healthy, pregnant women in terms of total antioxidant status (TAS), total oxidant status (TOS), oxidative stress index (OSI), native thiol, total thiol, disulfide, disulfide/native thiol, disulfide/total thiol, native thiol/total thiol, and U-II values. It is necessary to conduct more extensive studies evaluating placental, maternal, and fetal oxidative stress in conjunction in order to investigate the role of oxidative stress in IUGR

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