Urokinase and its receptor uPAR is a critical component of pulmonary renal cascade and is significant for pulmonary function and contributes to the physiological regulation; relationship with Serpin E2

Manoj G Tyagi,Vikram Gs,Vishakha Tyagi,S Thirumalai Velu,Dharmendra Singh

doi:10.32553/jbpr.v8i3.627

Abstract

Many previous studies have shown that induction of uPA, uPA receptor (uPAR), and PAI-1 may occur in lung endothelial cells (ECs) through a uPA-mediated feedback pathway. Soluble urokinase-type plasminogen activator receptor (suPAR) is a soluble form of the urokinase plasminogen activator receptor (uPAR) that is produced upon cleavage of membrane-bound uPAR. It is found in various body fluids, including blood, urine and cerebrospinal fluid. It is now known that Pulmonary function in physiological and patho-physiological condition is regulated by these molecules. On the other hand, Protease nexin-1 or serine protease inhibitor (Serpin E2) is intricately linked in the physiological homeostasis and interacts with uPA system. These are the key elements of the pulmonary renal cascade regulating multiple physiological functions. Key words: Urokinase, suPAR, lungs, SERPIN, physiological, airways

Highlights

The urokinase plasminogen activator receptor is a three-domain membrane-bound receptor, mainly expressed on immune cells i.e activated T cells, neutrophils and macrophages, and on smooth muscle and endothelial cells
Many previous studies have shown that induction of uPA, uPA receptor, and Plasminogen activator inhibitor-1 (PAI-1) may occur in lung endothelial cells (ECs) through a uPA-mediated feedback pathway
Soluble urokinase-type plasminogen activator receptor is a soluble form of the urokinase plasminogen activator receptor that is produced upon cleavage of membrane-bound uPAR

Summary

Introduction

The urokinase plasminogen activator receptor (uPAR) is a three-domain membrane-bound receptor, mainly expressed on immune cells i.e activated T cells, neutrophils and macrophages, and on smooth muscle and endothelial cells. During inflammatory stimulation, shedding of uPAR from the plasma membrane is the main process of soluble urokinase plasminogen activator receptor (suPAR) formation.

Results

Conclusion