Abstract
Uroguanylin is a novel natriuretic and diuretic peptide originally isolated from urine. To determine whether uroguanylin has a physiologic role during the perinatal period, uroguanylin levels in umbilical cord plasma obtained at the time of delivery were measured by radioimmunoassay and compared with cord serum osmolality. Mean (+/- SD) cord plasma uroguanylin concentrations (8.8 +/- 2.1 fmol/mL) were higher compared with normal adult values. The extent of maturity, mode of delivery and gender did not appear to influence cord uroguanylin levels. The uroguanylin concentration had a significant positive correlation with cord serum osmolality. These findings support some regulatory role of this peptide in perinatal renal and cardiovascular adaptation.
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Schedule a callMore From: Pediatrics international : official journal of the Japan Pediatric Society
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