Abstract
In the now classic 1985 fantasy-comedy film Back to the Future , teenager Marty McFly travels back in time 30 years in a DeLorean sports car/modified time machine and fortuitously befriends the younger version of his father. Marty finds his father to be a meek high school teenager and realizes that Biff Tannen, the bullying supervisor of the future version of his father, was also his father’s bully in high school. What was true then is true now. Article see p 766 In this issue of Circulation: Heart Failure , Verbrugge et al1 bring an old concept back to the present by proposing the use of urine sodium (Na+) and chloride (Cl−) concentrations in guiding diuretic therapy for the treatment of heart failure. In this prospective cohort study, the investigators recruited patients with heart failure and worsening congestive symptoms, evidence of left ventricular ejection fraction <45% by echocardiogram, or clinical signs of volume overload. Study subjects were observed in an intensive care unit setting and placed on a low NaCl diet (<3 g per day) with restricted fluid intake (1.5 L). They received a bolus of intravenous bumetanide in 3 consecutive 24-hour intervals, typically in combination with spironolactone±vasodilators and their usual medications for heart failure, including β-adrenergic antagonists and renin–angiotensin system blockers. In some cases, chlorthalidone and acetazolamide were added. Echocardiograms were performed at baseline and after the 3-day period. Urine was collected for 3 consecutive 24-hour intervals. Baseline …
Published Version (
Free)
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
