Abstract
There are several reasons for treating calcium oxalate (CaOx) stone-formers with alkali. The inhibition of CaOx crystal growth in diluted urine increases with increasing pH1,2, and in urine with a high CaOx supersaturation the in vitro crystallization of CaOx is reduced when pH was above 6. Consequently CaOx crystals are encountered only in urine with a low pH4,5. Furthermore urinary citrate, which is a determinant of the ion-activity product of CaOx6 and an inhibitor of CaOx crystallization7−9, is low in patients forming CaOx stones10−12. With this background it was of interest to study in more detail the effect of alkali on urine composition in a group of recurrent CaOx stone-formers.
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