Abstract
Increased or unchanged urinary zinc excretion has been reported in hypertension. In the present article, this observation was confirmed in a group of 10 untreated hypertensive patients of both sexes that had no diabetes or obesity. The 24-h zinc excretion was significantly different between the patients: 7.46+/-3.01 micromol and healthy controls: 5.19+/-2.19 micromol (p<0.025). After a 1-mo treatment with 4 mg perindopril per day, a decrease of urinary zinc was observed until it reached levels not significantly different from those of the healthy controls (5.98 +/- 2.13 micromol). The decrease was significantly different from that of the pretreatment values (p<0.05).
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