Abstract
Levels of urinary tryptophan metabolites anthranilic acid (AA), 5-hydroxyindoleacetic acid (5HIAA), and indoleacetic acid (IAA) were measured by HPLC for 24 diabetic (insulin dependent diabetes mellitus; IDDM) and 12 non-diabetic human juveniles. A single urine collection was used to examine tryptophan metabolism by ratio comparisons of AA:5HIAA and AA:IAA. Ratios were calculated from peak areas. Ratios of AA:5HIAA were significantly (p=0.0001) lower in diabetic juveniles (0.19) compared to juveniles without diabetes (1.18). Ratios of AA:IAA were also significantly (p=0.0001) lower in juveniles with diabetes (0.54) compared to juveniles without diabetes (4.29). Neither race nor gender had a significant effect on ratios. These data suggested altered activity in the kynurenine pathway in IDDM subjects. Within the experimental group, ratios of AA:5HIAA were significantly (p=0.0191) different between subjects with Finger Stick Blood Sugar (FSBS) values that were below 70 mg/dl compared to those with levels between 100–250 mg/dl. No other significant effects (Hemoglobin A 1C, insulin concentration or duration of disease) were found within the experimental group.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
