Abstract
Tissue samples from all portions of the urinary collecting system were assayed for the presence of tissue fixed plasminogen activator activity. Daily urine samples were obtained from 17 patients following urinary tract surgery and assayed for the presence of fibrin-fibrinogen degradation products (FDP). Hematuria was present in all samples. Urine samples were obtained from 17 patients with chronic renal disease and proteinuria and similarly assayed for FDP. All portions of the urinary collecting system contained considerable tissue fixed plasminogen activator activity. All patients with hematuria had FDP present in the urine, indicating that fibrinolysis is the process by which the clots are removed from the urinary tract. These results indicate that correlation of urinary FDP with renal parenchymal disease should be attempted only in the documented absence of hematuria.
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