Urinary soluble triggering receptor expressed on myeloid cells-1 is an early predictor for sepsis outcome and sepsis-induced acute kidney injury

Abstract

Background Recent reports had indicated the usefulness of urinary soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) as a prognostic marker for sepsis and sepsis-induced acute kidney injury (AKI). Objective This study aimed to detect the prognostic value of urinary sTREM-1 in sepsis in terms of the clinical course, development of AKI, and the survival rate. Patients and methods Thirty critically ill patients with sepsis were included (57.6±7.5 years, 18 men), in addition to a group of 10 controls (45.6±3.5 years, six men). Urinary sTREM-1 and C-reactive protein serum levels were estimated on admission, and days 3 and 7. The sepsis-related organ failure assessment scoring system was calculated at baseline and daily until discharge, mortality, or up to 28 days. Length of stay in ICU, need for vasopressors, mechanical ventilation or hemodialysis, and development of AKI and the outcomes were recorded. Results Compared with stable patients, patients who required vasopressors (23 patients) or hemodialysis (patient 4) showed significantly higher sTREM-1 values (4.06±1.22 vs. 2.86±0.51 ng/ml, P Conclusion Urinary sTREM-1 can be used as a clinical outcome predictor for the development of AKI and ICU mortality in patients with sepsis.