Urinary proteinase activity in patients with acute renal failure after trauma and kidney transplantation.

Abstract

A pathophysiological stress that produced a “hypercatabolic” metabolic state often will cause an increased basal energy expenditure in addition to eccessive loss of body protein. This condition is further characterized by severe muscle wasting and increased urinary nitrogen excretion. Both protein synthesis and breakdown are stimulated in severe skeletal trauma (Birkhahn et al., 1981), sepsis (Long et al., 1977) and after burn (Kien et al. 1978). Under these conditions enhanced proteolytic activity in plasma ultrafiltrates and urine fractions of patients with severe trauma and acute renal failure has been reported (Hörl and Heidland, 1980; Hörl et al., 1981; 1982a; 1983; 1986). Until now, the effect of postischemic acute renal failure on urinary protease excretion has not been investigated. Therefore, the present study was undertaken to compare urinary protease activity in patients with acute renal failure after cadaveric kidney transplantation and following multiple traumatic injuries. Furthermore, the proteolytic enzymes involved were partly characterized.KeywordsAcute Renal FailureKidney TransplantationCyanogen BromideSubunit StructureNormal Kidney FunctionThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.