Abstract
Summary1. Urinary acid mucopolysac-charide-glycopeptide fraction and its enzymic digest were fractionated on Dowex 1-X2 column, chloride form. The chemical composition of the eluates was determined. 2. The acid mucopolysaccharide-glycopeptide fraction of normal urine contains a mixture of acid mucopolysaccharide-glycopeptide complexes (70-80%) with a small amount of free acid mucopolysaccharide (20-30%). With increasing age, there were higher percentages of bound acid mucopolysaccharides and less free acid mucopolysaccharides in urine. 3. After enzymic digestion, there was an increase of chondroitin sulfate A or chondroitin sulfate C and a decrease in bound acid mucopolysaccharides in 0.5 M and 1.25 M NaCl eluates. With increasing age, a smaller proportion of the glycopeptides could be digested with a mixture of pronase, trypsin and papain. 4. In normal subjects, 60-90% of acid mucopolysaccharides are equally distributed between the 1.25 M and 1.5 M NaCl fraction. With increasing age, less acid mucopolysa...
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Schedule a callMore From: Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)
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