Abstract
Abstract In order to learn whether urinary m -hydroxyphenyl acids are mainly microbial in orgin, following the oral administration of quercetin the phenolic acid content of urine from neomycin-treated rats has been compared with that of urine from rats not treated with neomycin. The three acids, 3,4-dihydroxyphenylacetic, homovanillic, and m -hydroxyphenylacetic, occurring characteristically in the urine from untreated rats following quercetin feeding, were not found in urine from neomycin-treated rats fed quercetin. However, dihydroferulic, p -hydroxyphenylpropionic, and p -hydroxybenzoic acids, and tentatively, isovanillic acid, were identified in the urine of the treated rats. None of these compounds was found in urine from neomycin-treated rats which were not fed queercetin. Several compounds whose identification has not been achieved have also been found, but no m -hydroxyphenyl acid have been identified thus far. These results strengthen the evidence for previous suggestions by others that urinary m -hydroxyphenyl acids appear to be primarily bacterial metabolites of certain dietary precursors, including flavonoid compounds.
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