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Abstract
We read with great interest the paper of Houston and colleagues entitled “Associations of Dietary Phosphorus Intake, Urinary Phosphate Excretion, and Fibroblast Growth Factor 23 With Vascular Stiffness in Chronic Kidney Disease”. 1 Houston J. Smith K. Isakova T. Sowden N. Wolf M. Gutiérrez O.M. Associations of dietary phosphorus intake, urinary phosphate excretion, and fibroblast growth factor 23 with vascular stiffness in chronic kidney disease. J Ren Nutr. 2012; (Accessed March 8, 2012. [Epub ahead of print])http://www.jrnjournal.org/article/S1051-2276(12)00006-4/abstract PubMed Google Scholar In a cross-sectional study, the authors studied 74 adult chronic kidney disease (CKD) patients (mean age 64 years, mean creatinine clearance 51 ± 19 mL/min, 64% males, 12% black, 29% diabetic, and 30% received calcium supplements) and declared that fibroblast growth factor 23 (FGF-23) was associated with serum phosphate (r = 0.24, P < .03) and creatinine clearance (r = 20.4, P < .001) but not with dietary phosphorus or 24-hour urinary phosphate excretion (P > .05 for both). Associations of Dietary Phosphorus Intake, Urinary Phosphate Excretion, and Fibroblast Growth Factor 23 With Vascular Stiffness in Chronic Kidney DiseaseJournal of Renal NutritionVol. 23Issue 1PreviewElevated serum phosphate concentrations are established risk factors for cardiovascular disease and mortality in chronic kidney disease (CKD). Independent associations of other indices of phosphorus metabolism, such as phosphorus intake, urinary phosphate excretion, or hormones that regulate these systems, like fibroblast growth factor 23 (FGF23), with markers of cardiovascular disease in CKD, have been studied in less detail. Full-Text PDF
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