Abstract
AbstractIncreased levels of benzoic acid‐precipitable aromatic compounds and glycoprotein‐associated peptide material are found in the urines of patients with schizophrenic psychoses and endogenous depressions. Factors with regulatory effects on aminergic transmission have been found. A working hypothesis is proposed whereby genetically determined peptidase insufficiency interacts with increased peptide levels of either endogenous and/or exogenous origin to cause the psychotic state. These disorders are probably multifactorial syndromes, displaying changes in several factors with bioactive effects.
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