URINARY OBSTRUCTION DUE TO TRIPELENNAMINE HYDROCHLORIDE

Abstract

Various side reactions from the use of tripelennamine hydrochloride (pyribenzamine® hydrochloride) have been observed. 1 Drowsiness, dizziness, gastric disturbances and headache have been the responses most commonly evoked. Less frequent in occurrence have been urinary burning and urinary frequency. In none of these reports has there actually been a description of a case involving urinary difficulty. I recently saw a patient whose reaction to tripelennamine involved the urinary tract and was so unusual that it appears worth recording. REPORT OF CASE On Feb. 25, 1949 a white man aged 54 complained of difficult urination of three days' duration. He had been examined periodically, and there was no reason to anticipate the occurrence of the predicament. Urination was of an obstructive character but was completely painless. Only a dribbling stream was possible. When the urethra was compressed against straining, thereby increasing the bladder pressure, the stream became full for about