Urinary neutrophil gelatinase-associated lipocalin and kidney injury molecule 1 measurements in children with urinary system diseases after contrast media administration and the evaluation of hydration therapy

Abstract

Objective To investigate the dynamic changes of neutrophil gelatinase-associated lipocalin(NGAL) and kidney injury molecule 1(KIM-1) in children after contrast media administration and evaluate the effect of hydration therapy. Methods A total of 58 patients with urinary system diseases who were admitted to Shengjing Hospital of China Medical University from March 2012 to March 2014 for intravenous pyelography(IVP) in pediatric department were enrolled.The 58 patients were randomly divided into hydration group of 28 patients and non-hydration group of 30 patients.Contemporaneous 24 patients received respiratory system enhanced CT examination without urinary tract diseases and hydration were enrolled as control group.Urine NGAL and KIM-1 of the three groups at 0 h, 24 h, 48 h, 72 h, 96 h after using intravenous contrast media were detected by ELISA.Serum creatinine of the three groups at 0 h, 48 h, 96 h after using intravenous contrast media were detected. Results All of the 82 subjects in this study didn′t occur contrast-induced acute kidney injury.The urinary NGAL of non-hydrated group significantly increased at 24 h and 48 h after contrast media administration(P 0.05). Conclusion The urine NGAL and KIM-1 of children with urinary system diseases increase after contrast media administration and there is a trend of spontaneous recovery.Hydration intervention can alleviate the upward trend of urine NGAL and KIM-1.For children receiving enhanced CT examination but without urinary system diseases, the change of urine NGAL and KIM-1 are not significant. Key words: Contrast; Neutrophil gelatinase-associated lipocalin; Kidney injury molecule-1; Serum creatinin