Urinary nephrin as a marker of nephropathy in obese prediabetic patients

Abstract

Background: One of the most important complications of obesity and prediabetes is nephropathy. In the Eastern Mediterranean area, the incidence of obesity is always growing. In Saudi Arabia, Egypt, Kuwait, the United Arab Emirates, and Bahrain, the highest level of obesity is found in 15-year-old adults and also in older adults. Obesity and overweight are prevalent in the preceding countries at rates ranging from 69% to 77% in men and 74% to 80% in women, making it critical to distinguish nephropathy in these patients for a better prognosis. Objective: To assess the level of urine nephrin as a nephropathy marker in obese and prediabetic patients. Patients and Methods: This was cross-sectional observational research that included 90 people. Their ages varied from 30 to 70 years old, and they came from Dar El-Shefa hospital's outpatient clinic between December 2019 and May 2020. The study was explained to all participants, and their informed consent was acquired before the start of the trial. The subjects were split into three groups: group I (thirty normoalbuminuric obese non-diabetic patients), group II (thirty normoalbuminuric obese pre-diabetic patients), and group III (thirty healthy control).