Urinary MMP-9/UCr association with albumin concentration and albumin-creatinine-ratio in Mexican patients with type 2 diabetes mellitus.

Víctor Gildardo Arcos-Sacramento,Jaime Morales-Romero,Arturo Rodríguez-Hernández,Mariel Alejandra Acuña-Hernández,Magda Elena Hernández-Hernández,Clara Luz Sampieri,Víctor Hugo Sandoval-Lozano,Rubén Arturo Orozco-Ortega

doi:10.7717/peerj.10474

Víctor Gildardo Arcos-Sacramento, Jaime Morales-Romero + Show 6 more

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https://doi.org/10.7717/peerj.10474

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Abstract

BackgroundChronic kidney disease is one of the most common complications of type 2 diabetes mellitus (T2DM), causing an increased risk of cardiovascular morbidity and mortality. Matrix metalloproteinase (MMP) activity has been proposed as useful biomarker for diabetic renal and vascular complications.MethodsA cross-sectional study was conducted among T2DM patients who attended a public secondary hospital in Mexico. We performed clinical, biochemical, and microbiological assessments, as well chronic kidney disease diagnosis according to the KDIGO guideline. Urinary MMP-9 was quantified by ELISA and adjusted using urinary creatinine (UCr).ResultsA total of 111 patients were included. Most participants were women (66%). Mean age was 61 ± 10 years and median T2DM duration was estimated at 11 years. Through multivariate analysis, MMP-9/UCr was found to be associated with albumin concentration and albumin to creatinine ratio.DiscussionValidation of non-invasive biomarkers of chronic kidney disease among T2DM patients is necessary. Here, we demonstrate MMP-9/UCr as a potential biomarker of albumin concentration and albumin to creatinine ratio in Mexican patients with T2DM.

Highlights

The prevalence in Mexico in 2016 of previously diagnosed type 2 diabetes mellitus (T2DM), and the combined prevalence of overweightness and obesity were 9.4% and 72.5%, respectively (Rojas-Martínez et al, 2018)
We found an association between renal impairment and the presence of urinary matrix metalloproteinase (MMP)-9 in T2DM (García-Tejeda et al, 2018)
glomerular filtration rate (GFR) and albumin to creatinine ratio (ACR) were estimated in 158 participants and, more than 3 months later, 137 patients returned for a second estimation of GFR and ACR

Summary

Introduction

The prevalence in Mexico in 2016 of previously diagnosed type 2 diabetes mellitus (T2DM), and the combined prevalence of overweightness and obesity were 9.4% and 72.5%, respectively (Rojas-Martínez et al, 2018). Chronic kidney disease (CKD) is a common complication of T2DM, which confers an increased risk of cardiovascular morbidity and mortality (Górriz et al, 2019). Urinary MMP-9/UCr association with albumin concentration and albumin-creatinine-ratio in Mexican patients with type 2 diabetes mellitus. Urinary matrix metalloproteinase (MMP) activity has been proposed as a sensitive, non-invasive, and clinically useful biomarker for diabetic renal and vascular complications; larger scale studies are necessary in order to confirm their utility (Zheng et al, 2012). Chronic kidney disease is one of the most common complications of type 2 diabetes mellitus (T2DM), causing an increased risk of cardiovascular morbidity and mortality. We demonstrate MMP-9/UCr as a potential biomarker of albumin concentration and albumin to creatinine ratio in Mexican patients with T2DM

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Results

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