Urinary mercury excretion in chloralkali workers after the cessation of exposure.

Abstract

Seventeen former chloralkali workers were followed through the regular determination of urinary mercury for nearly two years after the cessation of exposure to mercury vapor in a study of the time course of urinary mercury elimination. Their duration of exposure ranged from 3 d to 35.5 years. A one-compartment model for urinary mercury elimination was applied. The urinary mercury concentration declined at a rate indicating a half-time of 91 d. When corrected for an individual base-line level of urinary mercury resulting from sources of mercury intake not related to work, the half-time was 72.4 [95% confidence interval (95% CI) 63.2-81.7] d, with a mean elimination rate constant of 0.011 (95% CI 0.008-0.013).d-1. The day-to-day variability of the urinary mercury concentration averaged 22%, expressed as the coefficient of variation between urine samples delivered on three consecutive days.