Urinary Malondialdehyde Is Associated with Visceral Abdominal Obesity in Middle-Aged Men.

Sun Min Lee,Jeong Gyu Lee,Eun-Ju Park,Yun Jin Kim,Dong Wook Jeong,Hye Rim Hwang,Junehee Han,Jeong Suk Jeon,Yu Hyeon Yi,Young Hye Cho,Sang Yeoup Lee,A Ra Cho,Young Jin Tak,Seung-Hun Lee

doi:10.1155/2015/524291

Abstract

The purpose of the present study was to investigate multiple anthropometric parameters used to evaluate obesity, particularly visceral abdominal fat area, and various metabolic parameters including malondialdehyde (MDA) as an oxidative stress marker. We evaluated various measures of obesity, including body mass index (BMI), waist circumference (WC), sagittal abdominal diameter, fat percentages using dual-energy X-ray absorptiometry, visceral fat area (VFA), subcutaneous fat area, multiple biomarkers related to metabolic disease, and urinary MDA, in 73 asymptomatic middle-aged men who were not severely obese. We examined relationships between multiple measures of obesity, metabolic markers, and urinary MDA levels and evaluated associations between VFA and urinary MDA. In the visceral obesity group, γ-glutamyl transferase (GGT), uric acid, and urinary MDA levels were significantly higher than in the nonvisceral obesity group (P = 0.008, P = 0.002, and P = 0.018). Urinary MDA (r = 0.357, P = 0.002) and uric acid (r = 0.263, P = 0.027) levels were only significantly positively correlated with VFA among measures of obesity. Urinary MDA, serum GGT, and serum CRP were significantly positively associated with VFA (P = 0.001, P = 0.046, and P = 0.023, resp.), even after adjusting for BMI and WC.

Highlights

Obesity is associated with hypertension, dyslipidemia, metabolic syndrome, and type 2 diabetes [1, 2]
Obesity is usually defined by body mass index (BMI), waist circumference (WC), or body fat percentage; these measures are limited in their ability to distinguish visceral obesity, which plays a key role in the pathogenesis of cardiometabolic syndrome
We demonstrated that urinary MDA, GGT, and Creactive protein (CRP) were significantly positively associated with visceral fat area (VFA), even after adjusting for BMI and WC

Summary

Introduction

Obesity is associated with hypertension, dyslipidemia, metabolic syndrome, and type 2 diabetes [1, 2]. Obesity is usually defined by body mass index (BMI), waist circumference (WC), or body fat percentage; these measures are limited in their ability to distinguish visceral obesity, which plays a key role in the pathogenesis of cardiometabolic syndrome. Their average BMI is low, Asians demonstrate higher fat percentages compared with. Many studies found higher oxidative stress levels in obese than nonobese people [12,13,14], which may be due to several potential mechanisms including chronic inflammation [15,16,17], hyperglycemia [18], or impairment of antioxidant defense

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Methods

Conclusion