Abstract
Fatty acid-binding proteins (FABPs) are a group of intracellular proteins of 14 kDa, belonging to the lipocalin family. FABPs play a key role in the binding and trafficking of fatty acids and some other hydrophobic molecules. In the human kidney, liver-type FABP (L-FABP) is expressed in the proximal tubule. L-FABP expression and secretion into urine is increased during tubulointerstitial damage in the kidney. Our research laboratory has developed L-FABP ELISA kit for diagnostic use in Japan. This chapter provides a brief summary of the urinary L-FABP monitoring with particular emphasis on its important roles in recent clinical studies (e.g., diabetic nephropathy, non-diabetic nephropathy, contrast-induced acute kidney injury, septic shock, kidney transplant, pediatric acute kidney injury).
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